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abstract

Hereditary Factor VII Deficiency in the Asian Elephant (Elephas maximus) Caused by a F7 Missense Mutation.

2017-01-24 - Pennsylvania, United States. Lynch M1, McGrath K2, Raj K3, McLaren P4, Payne K5, McCoy R4, Giger U3.

A wild-caught, 41-yr-old male Asian elephant ( Elephas maximus ) without an apparent increased bleeding tendency was consistently found to have prolonged prothrombin times (PTs, mean = 55±35 s) compared to 17 other elephants (PT=10±2 s). This elephant´s partial thromboplastin times (PTT) fell within the normal range of the other elephants (12-30 s). A prolonged PT in the presence of a normal PTT suggests disruption of the extrinsic pathway via deficiency of coagulation factor VII (FV...


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research
Penn State scientists decoded 80 percent of the wooly mammoth genome, making it more likely that these extinct animals could be cloned.

DNA Discovery May Bring Long-extinct Wooly Mammoth Back to Life

2008-12-10 - Pennsylvania, United States.

Scientists have mapped out most of the genetic code of the wooly mammoth, marking the first time an extinct animal’s DNA has been decoded and raising the possibility that the creature could be cloned and return to life. Wooly mammoths, which roamed the planet 10,000 years ago, are relatives of the modern African Elephant, but were covered with thick hair, had larger tusks and smaller ears.


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evolution
Matt Hillsman, curator of the Blackwater Draw Museum, said Columbian mammoths roamed the Eastern New Mexico plains up to 10,000 years ago. A model of a older bull Columbian mammoth was built by students in the 1960’s.

Five things you might not know about ...Mammoth comeback

2008-11-22 - Pennsylvania, United States.

Scientists are a decade or two away from recreating the extinct woolly mammoth, according to a Pennsylvania State University researcher. The Colombian mammoth, the southern cousin of the woolly mammoth, roamed the eastern New Mexico plains up to 10,000 years ago. Matt Hillsman, the curator of Eastern New Mexico University’s Blackwater Draw Museum, said remains of the Colombian mammoth were found at the Black Water Draw dig site.


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abstract

Sequencing the nuclear genome of the extinct woolly mammoth.

2008-11-20 - Pennsylvania, United States. Miller W, Drautz DI, Ratan A, Pusey B, Qi J, Lesk AM, Tomsho LP, Packard MD, Zhao F, Sher A, Tikhonov A, Raney B, Patterson N, Lindblad-Toh K, Lander ES, Knight JR, Irzyk GP, Fredrikson KM, Harkins TT, Sheridan S, Pringle T, Schuster SC., Pennsylvania State University, Center for Comparative Genomics and Bioinformatics

In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths and noted differences among individual specimens. Subsequently, DNA sequences have been published for a number of extinct species. However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused on short mitochondrial sequences, never yielding more than a fraction of a per cent of any nuclear genome. Here we describe 4.17 billion bases (Gb) of sequence from several mammoth ...


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evolution
This is a life-size model mammoth at the Ice Age Museum in Moscow

Woolly-mammoth gene study changes extinction theory

2008-06-10 - Pennsylvania, United States.

A large genetic study of the extinct woolly mammoth has revealed that the species was not one large homogenous group, as scientists previously had assumed, and that it did not have much genetic diversity. "The population was split into two groups, then one of the groups died out 45,000 years ago, long before the first humans began to appear in the region," said Stephan C. Schuster, associate professor of biochemistry and molecular biology at Penn State and a leader of the research team. "This di...


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5 Headlines about Elephants from Pennsylvania2017-01-24 - Pennsylvania, United States - Hereditary Factor VII Deficiency in the Asian Elephant (Elephas maximus) Caused by a F7 Missense Mutation. 2008-12-10 - Pennsylvania, United States - DNA Discovery May Bring Long-extinct Wooly Mammoth Back to Life 2008-11-22 - Pennsylvania, United States - Five things you might not know about ...Mammoth comeback 2008-11-20 - Pennsylvania, United States - Sequencing the nuclear genome of the extinct woolly mammoth. 2008-06-10 - Pennsylvania, United States - Woolly-mammoth gene study changes extinction theory

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