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Hereditary Factor VII Deficiency in the Asian Elephant (Elephas maximus) Caused by a F7 Missense Mutation.

, Lynch M1, McGrath K2, Raj K3, McLaren P4, Payne K5, McCoy R4, Giger U3.

A wild-caught, 41-yr-old male Asian elephant ( Elephas maximus ) without an apparent increased bleeding tendency was consistently found to have prolonged prothrombin times (PTs, mean = 55±35 s) compared to 17 other elephants (PT=10±2 s). This elephant´s partial thromboplastin times (PTT) fell within the normal range of the other elephants (12-30 s). A prolonged PT in the presence of a normal PTT suggests disruption of the extrinsic pathway via deficiency of coagulation factor VII (FV...



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